Vo2Max and Heart Health Correlation With DFAA-1 and other Metrics

I recently stumbled across a Substack post by Dr. Paddy Barrett that explains how Vo2Max is impacted by low intensity exercise. While I had not known about Dr. Barrett previously, when I read his history and other posts, I became intrigued. I think he’s a world-renowned Cardiologist who focuses on heart health, and his posts discuss exercise, diets, supplements and lifestyle recommendations. In a way, I’m reminded of Dr. Ken Cooper of the Aerobics Institute, but Dr. Barrett is about half Dr. Cooper’s age.
The article I am referencing for this post discusses Vo2max, and ways to raise that value. But Dr. Barrett makes a unique argument. The article states that there are ways to RAISE Vo2max, but there is a different way to obtain your HIGHEST Vo2Max. They’re different things. Honestly, I had never thought of Vo2Max in this way, so I dug deeper.
Raising Vo2Max Is All About INTERVALS

Intervals. Boy, do I know a lot about intervals. Short-Sharp, Medium-Hard, Tabata, Zonneveld, 2×20’s, Fibonacci’s, Reverse-Fibonacci’s. I know Intervals. Intervals are hard. They strain the cardio-vascular system. They FEEL like results. Intervals are NOT boring.
Intervals, especially intervals that are inside of, say, six minutes in duration, will improve Vo2Max over time. I routinely perform six-to-eight-week blocks of Vo2Max efforts to raise not just my Threshold for economy (another metric that benefits from Vo2Max intervals), but also my ability to perform in the Supra-Threshold Realm. This level of intensity creates a massive bath of lactate, and requires a LOT of MCT1’s and MCT4’s (Monocarboxylate Transporters) to convert that lactate back into energy. Vo2Max efforts build those MCT1’s and 4’s, and they grow the muscles of the heart as well.
Vo2Max Intervals will raise Vo2Max… relative to an original value…
But not two sentences later, Dr. Barrett talks about the ‘Other’ component of Vo2Max; the highest overall value a cyclist can obtain. So intervals improve Vo2Max, but they don’t necessarily help you achieve your highest possible overall value.
Achieving Your HIGHEST FEASIBLE Vo2Max… Is All About BASE TRAINING!
Base. I write about it. I try to achieve it with AlphaHRV and DFAA-1, both for myself and my clients. I use a Moxy Monitor to observe muscle oxygen percentages that correspond with Ventilatory Threshold 1 and Ventilatory Threshold 2. We also study basic, old-fashioned heart rate, and of course, power/watts.
Dr. Cooper called it ‘LSD’, for Long, Steady Distance. The popular term these days is ‘Zone 2’. It’s an intensity that is assertive, but not overly so. It’s aerobic. It relies on fat for the majority of the fuel that is used.
But Dr. Barrett has one comment in the article that stands out…
“Stroke volume and left ventricular dilation are at their maximum between 40 – 60% of V02 Max 6.
Above 60% of V02 Max, stroke volume decreases, and the heart does not reach its full dilation capacity (LVEDD).
For most people, 40 to 60% of V02 Max is a relatively low intensity.
Usually a good big serving of Zone 1 and some Zone 2.
As you train these zones, your resting heart rate will decrease.
Therefore, for each heartbeat, your heart will fill even more, and the heart will dilate even more.
This intensity is where most people should be spending most of their time.”
And it’s the BOLD part that really struck me.
I can actually measure 40-60% of Vo2Max on my Vo2Master. Furthermore, I’ll pair that metric with traditional heart rate, DFAA-1, Muscle Oxygen, Power, and even cadence, to assess just what those values are in relation to that Vo2Max range. It’s a study of N=1, with a workout count of N=1, but if the numbers correlate with my own observations from previous rides, then it’s an affirmation that all my geek measurements are actually valid… at least for me.
Let’s Take A Ride.
On January 5th, 2025, I rode a ‘Base’ ride with my clients on VQ Velocity. I used the Vo2Master mask, a Moxy Monitor, the AlphaHRV Field on a Garmin 1040, and a power meter.
You can find this ride and others in an app that a client, Kenneth O’Brien, built for me so that we could assess this information in this way.
For this ride, the file in the drop-down menu reads ‘RW-01-05-25-drp-protocol‘.
I used the mask for about 28 minutes of the effort. The mask was calibrated with a 3 liter plunger, and was calibrated for O2.
Based on efforts in late December, I am highly confident that my Vo2Max (IN INTERVALS….!) is about 60ml/kg/min (See the file dated ‘RW-12-22-24’ in the app).
40% of 60ml/kg/min = 24
60% of 60ml/kg/min = 36
For the Best twenty minutes of this ride, here are my averages…

This next image changes the ‘Max Average Basis’ to traditional heart rate, which just serves to shuffle the columns a bit, to make it easier to see the data.

Now – let’s look at DFAA-1 via AlphaHRV:
If you read through this blog post from November of 2024, you’ll see that the values on the charts above are very similar to the charts and averages from two months earlier.
- VO2 for that base ride was 38ml/kg/min. That checks with the 40ml/kg/min upper limit.
- Average heart rate was 136 beats per minute. This is the same.
- Average power was 170 watts in November, and 166 watts in January. This is VERY similar.
- DFAA-1 averaged 1.34 in November, and it averaged 1.19 for this ride. Both values are above my stated goal of 1.10 or even 1.15.

CONCLUSION
Dr. Paddy Barrett’s article states that the heart chambers will dilate more fully at an intensity between 40 and 60% of Vo2max. However, it’s hard to get Vo2 values because of the cost of the equipment.
Therefore, we need to determine whether other methods of physiological tracking are equally valid.
- Vo2 for the effort was just under 60%. CHECK.
- Traditional Heart Rate was below 140bpm, which an earlier blog post determined was the upper limit of my VT1 breakpoint. CHECK.
- AlphaHRV recorded an average DFAA-1 at 1.19, which is above the 1.10-1.15 value that I have determined is the equivalent breakpoint for Threshold 1. CHECK.
- Traditional wattage was about 170 watts, give or take. This is below my self-prescribed Threshold 1 as well. CHECK.
I think we can safely affirm that the combination of using AlphaHRV, Traditional Heart Rate, and maybe a rolling 30-second view of wattage, will give us a high level of confidence that we are safely and effectively cycling to improve Vo2Max. Following AlphaHRV values allows my athletes to ride for the most effective value OF THAT DAY. This eliminates Physics (wattage), and emphasizes recovery, hydration, fatigue, temperature, and more. Let’s go with the Physiological parameters for accuracy; we can worry about performance later.
Thanks for reading, and
#ENJOY THE RIDE!